Functions of conserved motifs in the RNA-dependent RNA polymerase of a yeast double-stranded RNA virus.
نویسندگان
چکیده
At least eight conserved motifs are visible in the totivirus RNA-dependent RNA polymerase (RDRP). We have systematically altered each of these in the Saccharomyces cerevisiae double-stranded RNA virus ScVL1 by substituting the conserved motifs from a giardiavirus. The results help define the conserved regions of the RDRP involved in polymerase function and those essential for other reasons.
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ورودعنوان ژورنال:
- Journal of virology
دوره 72 5 شماره
صفحات -
تاریخ انتشار 1998